How can a person "cope" if their body refuses to accept medication?

I do not receive ANY benefits from medication… at all.
I have fibromyalgia and I am insulin resistant.
I think these two problems are part of what explains why I can't take neds.
I think my system is so screwed up that it just gets all the wrong messeges.

What can you tell me?
Do you have similar experiences… or any advice?
Aspirin messes with my asthma.
Antibiotics gave me a systemic yeast infection and caused the asthma.